Duke Box 90325
Durham, NC 27708-0325
125 Science Drive, 4104 French Family Science Center
Durham, NC 27708
Webpages
Gregory Allan Wray
Professor of Biology
Director of the Center for Genomic and Computational Biology
Professor of Biostatistics and Bioinformatics
Professor of Biostatistics and Bioinformatics
Professor of Cell Biology
Professor of Evolutionary Anthropology
Professor of Biostatistics and Bioinformatics
Core Faculty in Innovation & Entrepreneurship
I study the evolution of genes and genomes with the broad aim of understanding the origins of biological diversity. My approach focuses on changes in the expression of genes using both empirical and computational approaches and spans scales of biological organization from single nucleotides through gene networks to entire genomes. At the finer end of this spectrum of scale, I am focusing on understanding the functional consequences and fitness components of specific genetic variants within regulatory sequences of several genes associated with ecologically relevant traits. At the other end of the scale, I am developing molecular and analytical methods to detect changes in gene function throughout entire genomes, including statistical frameworks for detecting natural selection on regulatory elements and empirical approaches to identify functional variation in transcriptional regulation. At intermediate scales, I am investigating functional variation within a dense gene network in the context of wild populations and natural perturbations. My research leverages the advantages of several different model systems, but primarily focuses on sea urchins and primates (including humans).
Research Areas
Education
- Ph.D., Duke University (1987)
- B.S., College of William and Mary (1981)
Publications
Genomic insights into<i>Plasmodium vivax</i>population structure and diversity in central Africa (12/2022)
Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. (06/2021)
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Mailing Address
Nicholas Institute for Energy, Environment & Sustainability
Box 90467
Durham, NC 27708
Street / Delivery Address
Nicholas Institute for Energy, Environment & Sustainability
140 Science Drive
Gross Hall, Suite 101
Durham, NC 27708
Jan
31
Time: 1:00 pm to 1:30 pm