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Toone, Eric John

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(919) 660-1506

eric.toone@duke.edu

Box 90346

Durham, NC 27708-0346

3236 French Science Center

Durham, NC 27708

Webpages

Courses

CHEM 394: Research Independent Study

CHEM 590: Special Topics in Chemistry

I&E 281: Basics of Technology Commercialization

CHEM 493: Research Independent Study

CHEM 494: Research Independent Study

Eric John Toone

Professor Emeritus of Chemistry

Professor of Chemistry

Faculty Director of the I & E Certificate Program

Member of the Duke Cancer Institute

Faculty Network Member of The Energy Initiative

Professor of Biochemistry

Professor of Biochemistry

Professor of Biochemistry

Bass Fellow

Bass Fellow

Pages

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Research Areas

Education

Ph.D., University of Toronto (Canada) (1988)
Ph.D., UniversityToronto (1988)
M.S., UniversityToronto (1985)
M.S., University of Toronto (Canada) (1985)
B.S., University of Guelph (Canada) (1983)

Publications

Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. (08/2023)

Degradation of Components of the Lpt Transenvelope Machinery Reveals LPS-Dependent Lpt Complex Stability in Escherichia coli. (01/2021)

Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC. (07/2017)

High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors. (10/2016)

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058. (05/2016)

Drug design from the cryptic inhibitor envelope. (02/2016)

Specific binding at the cellulose binding module-cellulose interface observed by force spectroscopy. (03/2015)

Diamond surface functionalization with biomimicry - Amine surface tether and thiol moiety for electrochemical sensors (05/2014)

Structural Modifications in Bilayered Molecular Systems Lead to Predictable Changes in Their Electronic Properties (04/2014)

Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC. (01/2014)

Mailing Address

Nicholas Institute for Energy, Environment & Sustainability
Box 90467
Durham, NC 27708

Street / Delivery Address

Nicholas Institute for Energy, Environment & Sustainability
140 Science Drive
Gross Hall, Suite 101
Durham, NC 27708

nicholasinstitute@duke.edu