Donald Patrick McDonnell

Chair, Department of Pharmacology & Cancer Biology
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine
Glaxo-Wellcome Professor of Molecular Cancer Biology, in the School of Medicine
Professor of Pharmacology and Cancer Biology
Professor in Medicine
Professor in Medicine
Professor in Medicine
Professor in Medicine
Professor in Medicine
Member of the Duke Cancer Institute

Pages

The research in our group is focused on the development and application of mechanism based approaches to identify novel therapeutics for use in the treatment and prevention of hormonally responsive cancers. Specifically we are interested in the pharmaceutical exploitation of the estrogen and androgen receptors as therapeutic targets in breast and prostate cancers and in defining how these receptors influence the pathogenesis of these diseases. These efforts have led to the discovery of several drugs that are currently being evaluated in the clinic as cancer therapeutics, and to the identification of potential biomarkers and predictors of response that can help to target the use of these new drugs. Most recently we have explored approaches to treat triple negative breast cancer and have identified an important pathway that links obesity/dyslipidemia and cancer risk.

Education

  • Ph.D., Baylor College of Medicine (1988)

Mailing Address

Duke University Energy Initiative
Box 90467
Durham, NC 27708

Street / Delivery Address

Duke University Energy Initiative
140 Science Drive
Gross Hall, Suite 101
Durham, NC 27708

919-613-1305