Klitzman, Bruce
(919) 630-7445
Plastic Surgery, Duke University Medical Center
Durham, NC 27710
0112 Baker House, Trent Dr
Durham, NC 27710

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Bruce Klitzman

Associate Professor Emeritus in Surgery
Associate Professor of Surgery
Associate Professor of Surgery
Associate Professor in Surgery
Associate Professor of Surgery
Assistant Research Professor in Cell Biology
Assistant Research Professor in Cell Biology
Assistant Research Professor in Cell Biology
Assistant Research Professor in Cell Biology
Assistant Research Professor in Cell Biology

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Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Education

  • Ph.D., University of Virginia (1979)

Mailing Address

Duke University Energy Initiative
Box 90467
Durham, NC 27708

Street / Delivery Address

Duke University Energy Initiative
140 Science Drive
Gross Hall, Suite 101
Durham, NC 27708

919-613-1305